Antibiotic Resistance of Escherichia Coli Isolated from Patients in Shahid Sadoughi Hospital, Yazd, Iran

OBJECTIVES: The enhancement of antibiotic resistance has been ascribed to a collection of microbial characteristics, the selective pressure of antibiotic use and social and technical vicissitudes that enhance the transmission of resistant organisms.The aim of this study was to investigate antimicrobial-resistance to Escherichia coli isolated from patients in Shahid Sadoughi hospital of Yazd. METHODS: Antimicrobial susceptibility to cefixime, cefotaxime, ceftazidime, ceftriaxone, ciprofloxacin, gentamicin, imipenem, cotrimaxazole and nalidixic acid was determined for 492 E. coli isolates obtained from patients in Shahid Sadoughi hospital of Yazd in 2012. RESULTS: In this study, imipenem was the most active agent (70.1% susceptible), followed by gentamicin and ciprofloxacin. High rates of resistance were observed to nalidixic acid (69.9%) and cotrimoxazole (62.2%). CONCLUSIONS: The investigation of antimicrobial susceptibility is essential, and will help to identify E. coli resistance to antimicrobial agents and attempt to limit its spread.